منابع مشابه
Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1.
Homer is a family of cytoplasmic adaptor proteins that play different roles in cell function, including the regulation of G-protein-coupled receptors. These proteins contain an Ena (Enabled)/VASP (vasodilator-stimulated phosphoprotein) homology 1 domain that binds to the PPXXF sequence motif, which is present in different Ca²⁺-handling proteins such as IP3 (inositol 1,4,5-trisphosphate) recepto...
متن کاملHomers at the Interface between Reward and Pain
Pain alters opioid reinforcement, presumably via neuroadaptations within ascending pain pathways interacting with the limbic system. Nerve injury increases expression of glutamate receptors and their associated Homer scaffolding proteins throughout the pain processing pathway. Homer proteins, and their associated glutamate receptors, regulate behavioral sensitivity to various addictive drugs. T...
متن کاملMolecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.
Homer proteins bind specifically to the C termini of the metabotropic glutamate receptor mGluR1alpha/a and mGluR5, play a role in their targeting and modulate their synaptic properties. We have discovered that extensive alternative splicing generates a family of 17 Homer proteins. These fall into two distinct groups of 12 "long" Homers, which all have a coiled-coil domain at their C termini, an...
متن کاملCerebral palsy and alcohol consumption during pregnancy: is there a connection?
Department of Obstetrics, C.S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock, Detroit, MI 48201, USA and Department of Gynecology and Psychology, C.S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock, Detroit, MI 48201, USA *Corresponding author: C.S. Mott Center for Human Growth and Development, Wayne State Universi...
متن کاملFactory “ Homers ” : Understanding a Highly Elusive , Marginal , and Illegal Practice 1 ☆ Michel
A “homer” is an artifact that a worker produces using company tools and materials outside normal production plans but at the workplace and during workhours. Despite legal, artistic and ethnographic evidence of their existence, silence surrounds homers. Along with this evidence, interviews conducted mostly with retirees from a French aeronautics plant are used to show that this silence is not li...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2007
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2161